Tennessee Cherokee: ᏔᎾᏏ, translit. Tanasi is a state located in the southeastern region of the United States. Tennessee is the 36th largest and the 16th most populous of the 50 United States. Tennessee is bordered by Kentucky and Virginia to the north, North Carolina to the east, Georgia, Alabama, and Mississippi to the south, and Arkansas and Missouri to the west. The Appalachian Mountains dominate the eastern part of the state, and the Mississippi River forms the state's western border. Nashville is the state's capital and largest city, with a population of 660,388. Tennessee's second largest city is Memphis, which has a population of 652,717.